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50 50 & Target IC50: 140 nM (human MPO) [1] In Vitro AZD5904 is a pselective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC 50 of 140 nM and has similar potency in mouse and rat

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Its unique structure allows it to cross the blood-brain barrier relatively easily, making it bioavailable when administered systemically

doi: 10.1111/resp.12662 [DOI] [PubMed] [Google Scholar] 74.Notartomaso S, Scarselli P, Mascio G, et al

Extracellular irons are absorbed by cells and enter mitochondria through SLC25A37 and SLC25A28