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To investigate the specific role of FOXO4, small interfering RNA (siRNA) was used for FOXO4 knockdown
Additionally, this study was reviewed by the Therapeutic Products Directorate (TPD) and the Natural and Non-prescription Health Products Directorate of Health Canada, and approvals were obtained on 1 August 2013 from the TPD, Ottawa, Ontario
Gel-forming antioxidant eye drop efficacy in rats To determine whether NAC or NACET in the gel-forming eye drop vehicle would provide protection of photoreceptor structure and function in vivo, we performed once daily dosing for a total of 3 doses prior to intravitreal PQ injection, then continued once daily administration for 7 doses after induction of retinal degeneration in Brown Norway rats