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No evidence of cardiac, hepatic, or renal toxicity, changes in serum lipids, or clinically relevant changes in laboratory parameters, vital signs, electrocardiograms, or abnormal findings upon physical examinations have been observed

Note: Vitamin B12 in an injectable dose, such as hydroxocobalamin, can have side effects that usually do not require medical attention, unless you have an allergic reaction to cobalt, which is contained in the injection

Administration of melatonin to a pregnant mother rat also increases the activity of glutathione (GSH) peroxidase, an antioxidant marker, in fetal brains 77

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10.1016/S0140-6736(10)61350-5 9 BrC.PovedanoJ

A reasonable hypothesis is that the rapid cycling allows the liver to respond quickly to the glutathione requirements of other tissues