Previously, investigators have shown that upon glucose challenge, DP-IV -/- mice have improved glucose tolerance, increased insulin, and increased active GLP-1, consistent with the role of DP-IV in the regulation of GLP-1
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Semaglutide mimics the functions of GLP-1, improving blood sugar control and promoting a feeling of fullness, which aids in weight loss
Even among the 5.5% of patients in the semaglutide group who actually gained weight , there appeared to be some cardiovascular benefit, though the effect was less pronouncedpossibly due to medication non-adherence
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