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The trade-off is a modest heart rate increase from the glucagon component -- typically 5-10 bpm at rest, transient, and clinically insignificant for most patients

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Peptides are sticky molecules

One study found that for every pound lost, four pounds of pressure are taken off the knees

Measurable weight loss typically begins appearing around day 10 to 14, though individual response varies based on genetics, starting dose, and baseline metabolism

However, the short half-life and dose-limited adverse gastrointestinal effects of GLP-1 have limited its clinical application