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doi: 10.1016/j.aca.2013.03.007

IL-6 deficiency attenuates skeletal muscle atrophy by inhibiting mitochondrial ROS production through the upregulation of PGC-1 in septic mice

It usually causes sudden, painless vision loss in one eye

It ranks first not because it is the most fashionable anti-ageing therapy but because its mechanism of action directly addresses more hallmarks of ageing simultaneously than any other single intervention currently available in IV form