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Further, our findings may not be generalisable to youth with severe hyperglycaemia or those on chronic treatment and, due to limitations in sample size, we were only able to explore potential mediators of metformin response

I heard from one reader, who had the CBS mutation, and this individual ended up with selenium toxicity due to this very reason

In fibroblast cells, the growth controlling transcription factor hairy and enhancer of split-1 (HES1) was identified 12