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This leads to the subsequent cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)

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Effects of growth hormone therapy on thyroid function of growth hormone-deficient adults with and without concomittant thyroxine-substituted central hypothyroidism