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The rax1-1 mutant is characterized by an enhanced APX2 gene expression due to a lesion in the gene encoding GSH1 concomitantly with a 50% reduced GSH content

Studies have shown that oxidative stress and microvascular changes induced by diabetes can damage the integrity of the BTB in diabetic patients, leading to the infiltration of harmful substances into the seminiferous tubules, thereby affecting spermatogenesis [268]