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Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin
Daily losses through urine, faeces, and desquamated cells amount to approximately 0.1% of body stores, meaning it can take 35 years for deficiency to develop in someone with normal stores who stops absorbing B12
Factors such as initial B12 levels, underlying medical conditions, certain medications, advanced age, and injection frequency can affect the absorption and utilization of B12, possibly shortening the duration of action
It's important to note that individual experiences can vary
Increased energy: The body needs B12 to create energy, which creates a boost in energy, mental clarity and focus, and improved mood