BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825, Causes Sustained Degradation of BRD4 and Modulation of Chemokine Receptors, Cell Adhesion and Metabolic Targets in Leukemia Resulting in Profound Anti-Leukemic Effects
Science 252 , 17081711 (1991)
The overexpression of PFKFB3 has been found not only in cultured lung fibroblasts stimulated by inflammatory cytokines [35, 45, 50], but also in myofibroblasts from IPF patients [12] and in lung tissues from different animal models of pulmonary fibrosis [12, 50]
The first one was taken at base line, while the second was taken from the nearest point to the first one after stoppage of treatment (3 months after start of treatment)
Too little creates weak repair, too much causes re-injury
Exp Biol Med (Maywood) (2008) 233:67488