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Examined for impacts on cellular senescence indicators in laboratory systems (e.g., SA--gal, SASP-related transcripts)

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Chest pain or irregular heartbeat These could indicate stress on the cardiovascular system and require urgent evaluation

In November 2019, the US Food and Drug Administration approved crizanlizumab-tmca (ADAKVEO, Novartis) to reduce the frequency of VOC in adults and pediatric patients aged 16 years and older with SCD

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