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"Following a thorough analysis of our previous Phase 2b data and trial design, we believe that with the preferred modified release formulation and future trial design optimization, we can advance a competitive oral GLP-1 molecule into registration enabling studies, with the goal of addressing the present and persistent medical needs of people living with obesity." The ongoing open-label, randomized study is evaluating the pharmacokinetics and safety of immediate- and modified release formulations of danuglipron administered orally in healthy adults 18 years or older

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Semaglutide improved histological markers of fibrosis and inflammation and reduced the hepatic expression of fibrosis- and inflammation-related gene pathways in two preclinical MASH models (47)