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Increased IGF-1 signaling has been associated with enhanced cognitive resilience and improved neuroplasticity, particularly in studies related to aging

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Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-B-dependent manner

This enhanced incretin effect contributes significantly to the metabolic benefits observed after bariatric surgery, including improved glycemic control independent of weight loss

Nevertheless, there is a higher risk of hypoglycemia than with single GLP- 1 treatment