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Symptoms include: Persistent fatigue and lack of motivation Decreased libido or erectile dysfunction Loss of muscle mass and strength Weight gain and slower metabolism Mood changes, irritability, and poor focus Reduced bone density A meta-analysis published in Clinical Endocrinology confirmed that TRT significantly increases lean body mass and decreases fat mass in hypogonadal men (Corona et al., 2016)

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Additionally, testosterone has been linked to enhanced mitochondrial biogenesis and improved oxidative capacity in skeletal muscle [27], factors relevant to muscle quality beyond absolute mass

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