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Participants : 46 healthy females aged 2550 years with Fitzpatrick skin types IV and V

Long exposure to high glucose concentration impairs the responsive expression of g-glutamylcysteine synthetase by interleukin-1b and tumor necrosis factor-a in mouse endothelial cells

Am J Physiol 276(3):G751-760

10.1016/S0140-6736(16)31679-8 54

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Potential mechanisms by which peptide exposure could influence surgical outcomes include dysregulated angiogenesis contributing to hematoma formation, altered inflammatory signaling affecting early wound healing, and perturbations in collagen organization that may influence soft-tissue integrity during the critical postoperative period