Moreover, gut barrier dysfunction was consistently observed in rodent models following microplastics exposure, marked by reduced expression of tight junction proteinsZO-1, Occludin, Claudin-1, and Claudin-5 (Jiang et al., 2023
formulation often requires careful pH and solvent selection
Cell 49 , 172185 (2013)
231 MontoyaJGHolmesTHAndersonJNMaeckerHTRosenberg-HassonYValenciaIJet al
For example, pH-responsive Janus MNMs can maintain structural stability in gastric acid, and upon reaching the intestine, trigger the release of loaded anti-inflammatory drugs via pH stimulation, reducing the colonic inflammation score by over 60% in ulcerative colitis (UC) model mice [33]
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