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Activation of MC1R triggers a signaling cascade that pushes the melanocyte toward producing more eumelanin (brownblack pigment) over pheomelanin (redyellow pigment), and increases overall melanin content

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Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you have a liver disease or diabetes

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Restoring IGF-1 by administering it seems to have promising effects, at least in rodent studies, but large-scale human data are missing to date (Fig