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Such NRF2 activation provides an adaptive mechanism capable of controlling naturally elevated ROS levels in these species due to high metabolic demands ( Gsta4 ) can activate NRF2 and significantly increase mouse lifespan (Singh et al., 2010)

[17] The ratio of reduced glutathione to oxidized glutathione within cells is a measure of cellular oxidative stress [18] [11] where increased GSSG-to-GSH ratio is indicative of greater oxidative stress

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J Endocr Soc 7:bvad074

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