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141 , 142 Also, the chronic tophaceous gout stage is the most advanced stage of the disease and is characterized by the presence of tophi, which are deposits of urate crystals in the soft tissues with the less severe inflammation compared to the early stage

Lipidomic and metabolomic signature of progression of chronic kidney disease in patients with severe obesity

455,456,457,458,459,460,461,462 Interestingly, several novel drug platforms have been reported in recent years

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Symptoms include trembling, sweating, confusion, palpitations, and hunger