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(11) Tesamorelin & Ipamorelin and Cognitive Improvement Studies have indicated that growth hormone and its secretagogues, such as Tesamorelin and Ipamorelin, might play a role in neuroplasticity, neuronal survival, and synaptic plasticity, all of which are considered critical for optimal cognitive performance

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This mechanism becomes clinically important when using high-dose oral supplements (typically 1000 micrograms or more), as it can provide adequate absorption even when the intrinsic factor pathway is impaired

The researchers used antisense oligonucleotide approaches to reduce NNMT specifically in adipose tissue