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These medications work by mimicking endogenous GLP-1, an incretin hormone that plays crucial roles in glucose homeostasis and appetite regulation

A physician may need to evaluate persistent vomiting, severe abdominal pain, signs of dehydration, worsening reflux, gallbladder symptoms, low blood sugar risk in patients using diabetes medications, kidney function concerns, unintentional under-eating, rapid weakness or muscle loss, and medication interactions

However, injection timing relative to meals can affect nausea

Well cover preparation, injection technique, and proper disposal to help you master each stage

The impact of these changes on GLP-1s purchased through employer sponsored health plans is not yet clear

In the main published Phase 2 obesity trial, fatigue was reported by 7% of retatrutide participants and 4% of placebo participants