Chapter 13: A Trip Down Memory Lane The History of Semaglutide and Tirzepatide Semaglutide and Tirzepatide have become popular weight loss medications, but they have interesting backstories
Nakamura K, Inokuchi R, Doi K, Fukuda T, Tokunaga K, Nakajima S, et al
Cristancho AG, Lazar MA
Your liver and kidneys flush drugs and other toxins out of your body
Key Points Compounded tirzepatide was temporarily allowed during supply shortages as an affordable alternative to brand-name versions FDA officially ended compounded tirzepatide sales after March 19, 2025, with courts upholding the decision in early May 2025 FDA-approved Mounjaro and Zepbound remain the legitimate way to access tirzepatide When tirzepatide came out in 2022, the weight loss results got everyone talking
Nausea is the most common side effect of both semaglutide and tirzepatide, particularly during dose escalation phases