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(Note that proteins also promote GLP-1 release, but the mechanics are not yet fully understood.) Specifically, in the presence of sodium, L cells promote calcium influx by inducing depolarization

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10.2337/diabetes.48.12.2270 94

First, endurance and aerobic athletes runners, cyclists, triathletes for whom L-Carnitine's primary fatty acid transport mechanism directly supports the fat-burning energy system that dominates at training intensities below the lactate threshold

However, as development progresses and products approach approval, safety data becomes more complex and decisions carry greater regulatory weight