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Veterinarians prescribe milk thistle/SAMe as a liver protectant for dogs with certain conditions, including: Liver toxicity when certain toxins have been ingested such as in Tylenol poisoning, xylitol (sugar substitute) poisoning, NSAID (non-steroidal anti-inflammatory) poisoning, mushroom poisoning, and sago palm poisoning, among others Long-term treatment with drugs that can cause liver irritation While SAMe is best known for providing liver support in dogs, research suggests that it can help with brain health to help dogs with dementia (cognitive dysfunction)