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An important characteristic of this stress hormone is the diurnal trend with a peak that is ten-times higher in the morning

Hiragi, S., Yamada, H., Tsukamoto, T., Yoshida, K., Kondo, N., Matsubara, T., Yanagita, M., Tamura, H., & Kuroda, T

Healthcare providers may recommend starting with a lower dose and gradually increasing it based on observed effects and patient tolerance

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For example, doses of 2-3 mg/kg/day, similar to that reported in platelets from PD patients, produced complex I inhibition with selective nigrostriatal degeneration and astrocyte activation [14,65]